Synthesis and Biological Evaluation of some Chalcone Derivatives
نویسنده
چکیده
The compound Pyrazole derivatives, is prepared from p – Amino benzoic acid and ethanol. Chalcone has been prepared by the condensation reaction of Ethyl-4-acetamido benzoate and different ten aldehydes. These chalcones are cyclized with hydrazine hydrate and glacial acetic acid under reflux condition give pyrazole derivatives. These compounds have been characterized by detailed spectral analysis and have been screened for their antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, and Staphylococcus aureus, Aspergillus Niger and Anti inflammatory activity (by invitro)
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